Light control protein channel nano valve developed successfully
In theory, building a nanodevice is not completely different from building other equipment. The engineer first designs the necessary components and then decides how to assemble them to achieve the desired function. However, the biggest difficulty in building nanodevices is that they must be effectively designed at this scale. Fortunately, evolution has successfully solved countless engineering challenges, and scientists can always find inspirational natural designs in the world of proteins.
Researchers at the University of Gothenburg and the BiOMaDe Technology Center in the Netherlands demonstrated the power of this approach. Ben Feringa explained that MscL is a membrane protein on E. coli. It is a conduit that controls the movement of substances into and out of the cell. It can be reversed or turned off under the action of light. In a natural system, this is a kind of safety. valve. He said: "It can prevent cells from bursting. If the pressure inside the cell is too large, the pores of the channel will open 3 nanometers, and many things will flow out. Therefore, it is a very good channel and can automatically open. The open, ideal state can control its opening and closing."
Normally, MscL is always tight due to hydrophobic interactions. However, if there is a considerable load, the MscL's small hole will be forced to open until the load disappears. Feringa and colleagues designed a reversible optical switch that charges under ultraviolet light and discharges under visible light. This switch is attached to a specific part of the MscL monomer and the engineered protein is sent to the synthetic membrane. The experiment confirmed that the ultraviolet light can induce the opening of the channel until it is re-closed under the action of visible light. In the second round of experiments, the researchers injected the modified MscL into the microliposomes, which contained fluorescent dyes. Experiments showed that in addition to a small amount of leakage, light can effectively regulate the fluorescent dye in the liposome. Release.
This is just an initial discovery, and researchers are improving this approach, and they hope that this technology can be applied to controlled drug delivery. Feringa has far greater goals, and he foresaw the enormous capabilities of these tiny devices and believe they can be the basic building blocks of precision nanodevices. He said: "In the field of nanotechnology, we rarely know how to integrate parts, how to assemble them and let them work properly." "When the basic principles are proven, the new challenge is to see how to make this nano valve and part The nanofluidic channels combine to perform the function of the valve."
Sintering Parts:
There are similarities with the production of ceramic powder sintering technology, are, therefore, a series of powder metallurgy new technology can also be used in the preparation of ceramic materials. Because of the advantages of powder metallurgical technology, it has become the key problem to solve new materials, plays an important role in the development of new materials in powder metallurgy products. Including milling and milling which is mainly metallurgical process, and powder metallurgy products and literal agreement. It is often far beyond the category of materials and metallurgy, often across multiple studies (materials and metallurgy, machinery and Mechanical) technology. Especially the modern printing metal powder 3D, in Mechanical Engineering Cheng, CAD, reverse engineering technology, layered manufacturing technology, numerical control technology, materials science, laser technology, makes the product technology of powder metallurgy technology has become a modern comprehensive more cross discipline.
Based on different raw material,we can make Carbon Steel Sintering and Stainless Steel Sintering parts.
Advantages:
Powder metallurgy has unique chemical composition and mechanical, physical properties, and these properties can not be obtained by traditional casting method. Be made directly using porous powder metallurgy technology, semi dense or fully dense materials and products, such as oil bearing, gear, cam, a guide rod, a cutter.
(1) The process of powder metallurgy technology can minimize alloy composition segregation, eliminate thick, uneven casting organization. In the preparation of high performance rare earth permanent magnetic materials, rare earth hydrogen storage materials, rare earth luminescent materials, rare earth catalyst, high temperature superconducting materials, new metal materials (such as Al-Li alloy, heat-resistant al super alloy, alloy powder, corrosion resistance of stainless steel, high-speed steel powder, intermetallic compound high temperature structural materials) plays an important role.
(2) It can be prepared by amorphous, microcrystalline, quasicrystals, nanocrystalline and supersaturated solid solution of a series of high performance etc. The balance of materials, these materials have excellent electrical, magnetic, optical and mechanical properties.
(3) It can be easily combined with various types, give full play to the characteristics of each element of the respective materials, is a kind of high performance metal based ceramic composite material and low cost technology.
(4) It can make special structure and properties of the production that ordinary smelting method can`t produce, such as a new type of porous biomaterials, porous membrane material, structure and function of high performance ceramic abrasive material.
(5) It can realize near net forming and automatic batch production, which can effectively reduce the production of resources and energy consumption
(6) It can make full use of ore tailings, steelmaking sludge, mill scale, scrap metal recycling as raw materials, is a kind of new technology can be effective and comprehensive utilization of renewable materials.
Manufacturing process:
(1) The production of powder. It includes powder preparation, mixing and other steps. For powder molding and plasticity improve powder usually add oil, rubber or paraffin as plasticizer.
(2) Pressing powder. Under the pressure of 15-600mpa, pressed into the desired shape;
(3) High temperature sintering furnace or vacuum furnace. In a protective atmosphere in sintering. Unlike metal melting, sintering at least one element is in solid state. The sintering process of powder particles by diffusion, recrystallization, welding, chemical, physical and chemical dissolution process of a series, as metallurgy products have a certain porosity.
(4) Postprocessing. In general, good Sintering Parts can be used directly. But for some high precision size requirements and has high hardness and wear resistance of the parts but also for sintering postprocessing. Postprocessing including precision pressing, rolling, extrusion, quenching, quenching, oil, And infiltration, etc.
Sintering Parts
Sintering Parts,Carbon Steel Sintering,Stainless Steel Sintering,High Performance Sintering Parts
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