Despite the strong suspicion between genetics and asthma, genetic mutations account for only a fraction of the risk of disease development, a new study suggests. Rarely low-frequency genetic mutations are thought to explain this missing genetic, but they cannot play an important role. There are more than 11,000 people in the coding region for the analysis of the genome. Scientists have found that mutations in only three genes are associated with the risk of asthma. These three genes include GRASP, GSDMB and MTHFR. Studies have shown that the gap is in the genetic understanding of asthma. "Previous studies may have overestimated the heritability of asthma, probably because these estimates are based on family members sharing the environment and the correlation between genes, which may exaggerate heritability," said Carole Ober, Department of Human Genetics, University of Chicago. Say.
Previous studies did not consider the interaction between genes and the environment. These risks of establishing individual asthma are particularly important. Catherine Igartua of the University of Chicago evaluated nearly 33,000 rare or low frequency mutations in more than 11,000 people of different races. She uses a technique that allows her to study a common mutation in a nation, but it is rare. These genes, involved in apoptosis-regulating protein scaffolds, and vitamin B9 metabolism, are unknown roles in asthma, so far. Although rare mutations may not contribute much to the risk of asthma in the population, these genes still serve as potential therapeutic targets for development. "We think that there will be greater impact than we have been studying rare mutations in common variants," Ober said.
Precipitated Calcium Carbonate
Uses: Can be used as filler in rubber, plastics, paper, paint and ink industries. Widely used in organic synthesis, metallurgy, glass and asbestos production. It can also be used as a medium seeding agent for industrial waste water, a antacid for stomach and duodenal ulcers, a detoxifying agent for acidosis, a SOâ‚‚ eliminating agent in SOâ‚‚-containing exhaust gas, a dairy cattle feed additive and an anti-sticking agent for oil felt . It can also be used as a raw material for tooth powder, toothpaste and other cosmetics.
Usually used as a filler, widely used in daily chemical industries such as artificial floor tiles, rubber, plastics, papermaking, coatings, paints, inks, cables, construction supplies, food, medicine, textiles, feed, toothpaste, etc., as a filler to increase products The volume is reduced, and the production cost is reduced.
Light Calcium Carbonate is made of limestone, and can be used in daily chemical products such as tooth powder, toothpaste, cosmetics, etc. It can also be used in organic synthesis, metallurgy, glass and asbestos production.
The particle size of light calcium is smaller than that of Heavy Calcium Carbonate, the oil absorption is larger than that of heavy calcium carbonate, and the price is higher than that of heavy calcium carbonate. They are all commonly used fillers in latex paint, and they are best used together. Light calcium is better in terms of sedimentation, but its oil absorption is greater than that of heavy calcium, and the price is generally more expensive than heavy calcium. Although it is not as stable as heavy calcium, it is stable. Even for exterior wall paint, its application amount is also very large. of.
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