ã€Chinese Instrument Network Instrument Development】 Recently, the Li Yang Marine Research Team of the Rapid Separation and Detection Research Group of the Dalian Institute of Chemical Physics, Chinese Academy of Sciences has successfully developed a new technology and equipment for high-flux exhalation gas detection. The relevant research results are published in American Chemistry. The Society of Analytical Chemistry (DOI: 10.1021/acs.analchem.6b01707).
Some of the body's metabolic products are transported by the blood to the lungs where they appear in the exhaled gases through gas exchange. Exhaled gases reflect the body's metabolic and pathological conditions. Some substances may even become biomarkers for certain diseases. For example, alkanes are markers of oxidative stress and acetone is a biomarker of diabetes. In recent years, more and more research has been conducted on using exhaled gas detection to find specific markers in diseases such as chronic airway inflammation, lung cancer, tuberculosis, enteropathy, liver cirrhosis, breast cancer, and gastric tube-oesophageal cancer. This set up a special organization called the International Association of Breath Research (IABR) and published a special magazine called "Journal of Breath Research" for exhaled gas detection.
Li Haiyang's research team used vacuum ultraviolet lamp (VUV) photoionization combined with time-of-flight mass spectrometry (HPPI-TOFMS) under high pressure to analyze human exhaled air, and realized the exhaled breath of acetone and isoprene in the human body within one minute of sampling time. Sensitive detection of ene, dimethyl sulfide, ethanol, acetic acid and other substances. At 100% relative humidity, this method enables the direct online detection of volatile organic compounds (VOCs) at concentrations as low as tens of pptV and has excellent sensitivity to benzenes, furans, sulfur and nitrogen compounds. Selectivity, which has important application prospects in the areas of pollution exposure analysis, occupational disease prevention and other fields. Compared with other exhaled breath detection methods, the biggest advantage of this technology is that it is less affected by humidity, especially for the large difficulty of detecting exhaled breath with a relative humidity of up to 100%, successfully eliminating various dehumidification methods will inevitably cause measurement to be measured. Loss of goods.
In recent years, Li Haiyang’s research team has always focused on the research of new technologies and methods for exhaled gas detection: it has pioneered the “dynamic-dilution new method†that uses ion mobility spectrometry (IMS) technology for analysis and detection of anesthetic agents, and has been accepted by the international academic community. Accreditation was awarded the 2015 highlights article by J. Breath Res. (J. Breath Res. DOI: 10.1088/1752-7155/9/1/1002). The continuous maturity of IMS technology has promoted its application in clinical practice. Through cooperation with the First Affiliated Hospital of Harbin Medical University, it successfully applied IMS instruments to the on-line monitoring of the propofol anesthetic agent in exhalation gas during surgery. Provides an important guarantee. In addition, the research team also applied IMS technology to achieve highly sensitive detection of NO, a biomarker of respiratory tract inflammation (J. Breath Res. DOI: 10.1088/1752-7155/9/1/1003), with conventional chemiluminescence and Compared to electrochemical sensor technology, IMS has a simple and fast advantage for NO analysis.
Exhaled gas detection has the advantages of non-invasive, non-invasive, convenient sampling, and continuous sampling. It is a new topic in the field of analytical chemistry and medicine, and more and more analytical instruments and analytical methods need to be explored. HPPI-TOFMS for human exhalation analysis is simple, fast, and requires no pretreatment. It is expected to be a high-throughput disease screening tool, and can be used for clinical analysis of large data samples, as well as low-cost, high-throughput, The accumulation of large sample data facilitates the discovery of new disease biomarkers.
The above research work has been funded by the National Major Scientific Instruments and Equipment Development Project, the National “863†Program and the National Natural Science Fund.
(Original title: Dalian Institute of Chemicals invented a new method for high-throughput exhaled gas analysis and detection and new equipment)
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